1,2,4-Trimethylbenzene

CASRN 95-63-6 | DTXSID6021402

Toxicological Review (PDF) (150 pp, 2.5 MB, about PDF)
IRIS Executive Summary (PDF) (10 pp, 315.4 KB, about PDF)
Supplemental Information on the IRIS Toxicological Review of Trimethylbenzene

IRIS Toxicological Review of Trimethylbenzenes (External Review Draft)

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Overview
Background
Downloads

Alert
Notice - This site contains archived material(s)

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Overview

EPA is conducting a peer review of the scientific basis supporting the human health hazard and dose-response assessment of trimethylbenzenes that will appear in the Integrated Risk Information System (IRIS) database.

Background

Trimethylbenzenes (TMB) are a mixture of three isomers: 1,2,3-, 1,2,4- and 1,3,5-TMB. TMBs are produced during petroleum refining, and 1,2,4-TMB makes up approximately 40% of a certain petroleum product (the C9 fraction) which is used as a component of gasoline. Because of this, vehicle emissions are a major source of TMBs. Other uses of TMBs include solvents in research and industry, dyestuff intermediate, paint thinner, and as a UV oxidation stabilizer for plastics.

History/Chronology
Date	Description
Feb 2012	EPA hosted an interagency science consultation meeting on the review of the draft Toxicological Review of Trimethylbenzenes.
May 2012	EPA sent an abbreviated version of the toxicological review containing only information on 1,2,3-trimethylbenzene for Interagency Science Consultation at the recommendation of reviewers.
Jun 2012	EPA released the external peer review draft of the trimethylbenzenes assessment for public review and comment. [Federal Register Notice June 29, 2012]

Status

Following external peer review and public comment, the assessment will be revised taking into consideration the comments received. It will then undergo a final internal review by EPA and other federal agencies and White House offices. After completing the review it will be posted to the IRIS database.

Download(s)

This download(s) is distributed solely for the purpose of pre-dissemination peer review under applicable information quality guidelines. It has not been formally disseminated by EPA. It does not represent and should not be construed to represent any Agency determination or policy.

IRIS Toxicological Review of Trimethylbenzenes (External Review Draft) (PDF) (138 pp, 1.9 MB, about PDF)
Supplemental Information for Trimethylbenzenes (External Review Draft) (PDF) (220 pp, 9.3 MB, about PDF)
Draft Charge to External Peer Reviewers (PDF) (6 pp, 213.9 KB, about PDF)

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